The Michigan Central Railroad reached Dexter from Detroit on July 4, 1841, just after Dexter's first depot was completed. Frederick H. Spier of Detroit designed the present depot, which was completed in record time. Work began on November 6, 1886, and at noon on January 19, 1887, the station opened. The plantings for the grounds came from railroad greenhouses at Niles and Ypsilanti. The depot had two waiting rooms, a ticket office and a baggage room. Passenger service ended at the Dexter depot in 1953.